Pharmacy

1Pharmaceutical Technology I

Tecnologia Farmacêutica I

Course code:9494325

Ana Isabel Henriques Dias Fernandes Pinto

Learning outcomes of the curricular unit:

Provide students with the theoretical and practical knowledge adequate to the design, formulation, production and quality control of oral solid dosage forms.
It is intended that students learn how to produce and control the quality of the dosage forms under study, and to promote: (a) the acquisition and development of research attitudes and reflection, (b) group work and, simultaneously, develop individual leadership and communication skills, as well as critical thinking.
At the end of this course students should be able to recognize the advantages and limitations of the use of the therapeutic dosage forms under study and apply the most recent scientific and technological knowledge in the maximization of their effectiveness.

Syllabus:
  1. PRE-FORMULATION
    Physical, chemical and organoleptic properties.
    Purity.
    Particle size, shape and surface area.
    Solubility and dissolution, partition coefficient and ionization constant.
    Crystal properties and polymorphism.
    Stability.
  2. PARTICLE SCIENCE AND POWDER TECHNOLOGY
    Particle size analysis.
    Particle size reduction.
    Mixing.
    Powder flow.
  3. ORAL SOLID DOSAGE FORMS
    Powders.
    Granules: granulation.
    Hard gelatin capsules.
    Soft gelatin capsules.
    Tablets: compression and compaction. Compressibility evaluation.
  4. COATING OF TABLETS AND MULTIPARTICULATES
    Film coating, sugar coating and compression.
    Raw materials, manufacturing technology, packaging and quality control.
Suggested Bibliography:
  • Lachman L, Lieberman HA, Kanig JL (eds) (2010) Teoria e Prática na Indústria Farmacêutica. 2nd ed., Fundação Calouste Gulbenkian, Lisboa. ISBN: 9789723109085.
  • Aulton ME & Taylor KMG (ed.) (2017) Aulton's Pharmaceutics: the Design and Manufacture of Medicines. 5th ed., Elsevier. ISBN: 9780702070051.
  • Florence AT & Attwood D (2016) Physicochemical Principles of Pharmacy. 6th ed., Pharmaceutical Press, London. ISBN: 978-0857111746.
  • Florence AT & Siepmann J (2009) Modern Pharmaceutics. 5th ed., Informa Healthcare, New York. ISBN: 9781420065701.
  • Jones D (2008) Pharmaceutics: Dosage Forms and Design. Pharmaceutical Press. ISBSN: 9780853697640.