Study Programmes

Biology and Genetics2

Biologia e Genética

Curse code:9219101

Isabel Maria Corrêa Calvente De Barahona

Learning outcomes of the curricular unit:

Acquisition of fundamental concepts regarding the functioning of living things, studying in detail the system live simpler which is the cell and their interactions with the environment, enables students to deepen the knowledge gained, i.e. the ability to explain molecular level the functioning of living things and understand different regulatory mechanisms are indispensable for the proper functioning of living beings. The acquired knowledge in molecular biology has implications for medical practice, particularly in understanding of different diseases which will be discussed and analyzed.

Syllabus:
  1. PRINCIPLES OF CELL ORGANIZATION AND FUNCTION
    Concept of cell and cell theory.
    General characterization of prokaryotic and eukaryotic cells.
    Macromolecules.
    Biological membranes.
    Organelles.
    General cellular functions.
    Viruses.
  2. CLASSIC and MOLECULAR GENETICS
    Genes and DNA molecules.
    Chromatin and chromosomes.
    Mendel analysis and exceptions.
    Concepts of diploid, dominant and recessive alleles.
    Genetic mutations and chromosomal alterations.
  3. MECHANISMS OF GENETIC EXPRESSION
    Transcription, post translation modifications and translation.
    Molecular mechanisms of gene expression regulation.
    Cell cycle, mitosis and meiosis mechanisms.
    DNA replication and repair.
  4. TRANSPORT MECHANISMS OF MOLECULES and INTRACELLULAR PROTEIN TRAFFIC
    Passage of small molecules and macromolecules through membranes.
    Secretion pathway.
    Protein traffic for different organelles.
  5. GENERAL AND SPECIFIC CELLULAR MOVEMENT OF NERVE CELLS
    Cytoskeleton.
    Microfilaments, microtubules and intermediate filaments.
 
Suggested Bibliography:
  • Lodish H, Berk A, Kaiser CA, Krieger M, Bretscher A, Ploegh H, Amon A & Martin KC (2016) Molecular Cell Biology, 8th ed., W.H. Freeman and Company, New York. ISBN-13: 978-1464183393
  • Cooper GM & Hausman RE (2013) The Cell, a Molecular Approach, 6th ed., Sinauer Associates, Inc., USA. ISBN: 978-1-60535-155-1
  • Alberts B, Johnson A, Lewis J, Morgan D & Raff M (2014) Molecular Biology of the Cell, 6th ed., Garland Publishing, Inc., London. ISBN-13: 978-0815344322
  • Alberts B, Roberts K, Lewis J, Hopkin K, Jonhson A, Walter P, Raff M & Bray D (2003) Essential cell biology: an introduction to the molecular biology of the cell, 2nd ed., Garland Publishing, Inc., New York & London. ISBN-13: 9780815334804

 

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