Forensic Sci.

Forensic Molecular Biology2

Biologia Molecular Forense

Curse code:8059227

Nuno Eduardo Moura dos Santos da Costa Taveira

Learning outcomes of the curricular unit:
  • To learn the theory and practice of molecular biology methods used in the detection, identification and characterization of macromolecules (DNA, RNA and proteins) relevant for forensic and criminal investigation.
  • Learn the principles of human genetics and heredity, as well as the principles of molecular evolution, populational genetics and forensic genetics.
  • Obtain detailed knowledge on the methods used to produce DNA profiles for forensic purposes, including DNA sequencing, allele-specific PCR, RFLPs, microarrays, autossomic and mitochondrial short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs).
  • Provide information on the most recent use of phylogenetic analysis to investigate cases of criminal transmission of microorganisms (HIV and HCV).
  • Learn the principles of quality control and statistical analysis of data collected for forensic purposes.
Syllabus:
  1. General methods in molecular biology.
  2. Principles of human genetics and heredity.
  3. Principles of population and evolutionary genetics applied to forensic science.
  4. Use of phylogenetic analysis to investigate cases of criminal transmission of HIV and HCV.
  5. Molecular biology applied to forensic and criminal investigation.
  6. Quality control and statistical analysis of molecular information collected for forensic purposes.
 
Suggested Bibliography:
  • Butler JM (2015) Advanced Topics in Forensic DNA Typing: Interpretation, Elsevier Academic Press, San Diego
  • Goodwin W, Linacre A & Hadi S (2007) An Introduction to Forensic Genetics, John Wiley & Sons. ISBN: 978-0-470-01025-9
  • Lewis R (2011) Human Genetics, 10th ed., McGraw-Hill Publishing Company. ISBN: 0073525308
  • Pinheiro MF (2010) Genética Forense. Perspectivas da Identificação Genética, Edições Universidade Fernando Pessoa, Porto. ISBN: 978-989-643-050-4
  • Lemey P, Salemi M & Vandamme AM (2009) The Phylogenetic Handbook. A Practical Approach to phylogenetic analysis and hypothesis testing, 2nd ed., Cambridge University Press. ISBN-13: 978-0-511-71963-9

 

 

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