Functional and Molecular Biology
Biologia Funcional e Molecular
Course code:9504116
Ana Clara Guerreiro de Oliveira Ribeiro
Learning outcomes of the curricular unit:
At the end of the curricular unit, student should be able to:
- Clarify the mechanisms responsible for cellular organization and to describe the main classes of biological molecules and metabolic pathways;
- Understand the cell at its structural, functional and dynamic levels, and so to understand the cell as part integrant of the organism;
- Demonstrate general knowledge about molecular events involved in biological processes and in aging;
- Understand and analyze, from the biochemical viewpoint, structural and functional modifications of the regulatory entities in living organisms that are responsible for the development of pathological conditions;
- Relate genetics and environmental factors to the functionality and disability of the individual;
- Relate mechanisms and / or cellular events with some of the future actions as Physiotherapist.
Syllabus:
- Molecular cell organization
- Introduction to the study of biological molecules
- Amino acids and Proteins
- Enzyme kinetics
- Carbohydrates
- Lipids
- Metabolisms
- Plasma membrane
- Cell-cell and cell-matrix adhesion
- Transmembrane transport
- Cytoskeleton
- Cell cycle. Chromatin and chromosomes
- Basic genetic mechanisms
- Mutagenesis, mutations and genetic variation
- Inheritance and chromosomal bases of genetic diseases
Suggested Bibliography:
- Lodish H, Berk A, Kaiser CA, Krieger M, Bretscher A, Ploegh H, Amon A, Scott MP (2016). Molecular Cell Biology, 8th ed., W. H. Freeman and Company, New York.
- Azevedo C, Sunkel CE (2012). Biologia Celular e Molecular. 5th ed. Lidel, edições técnicas, Lisboa.
- Griffiths AJF et al. (2015). An Introduction to Genetic Analysis. 11th ed., W. H. Freeman.
- Quintas A, Ponces A, Halpern MJ (2008) Bioquímica: Organização Molecular da vida, Lidel, Lisboa, Portugal.
- Nelson DL, Cox MM (2004) Lehninger Principles of Biochemistry. 4th ed., Worth Publishers Inc., New York, EUA.
- Devlin TM (2001) Text Book of Biochemistry with Clinical Correlations, 5th ed., Wiley-Liss, New York, EUA.