Physiotherapy

Functional and Molecular Biology2

Biologia Funcional e Molecular

Course code:9504116

Ana Clara Guerreiro de Oliveira Ribeiro

Learning outcomes of the curricular unit:

At the end of the curricular unit, student should be able to:

  • Clarify the mechanisms responsible for cellular organization and to describe the main classes of biological molecules and metabolic pathways;
  • Understand the cell at its structural, functional and dynamic levels, and so to understand the cell as part integrant of the organism;
  • Demonstrate general knowledge about molecular events involved in biological processes and in aging;
  • Understand and analyze, from the biochemical viewpoint, structural and functional modifications of the regulatory entities in living organisms that are responsible for the development of pathological conditions;
  • Relate genetics and environmental factors to the functionality and disability of the individual;
  • Relate mechanisms and / or cellular events with some of the future actions as Physiotherapist.
Syllabus:
  1. Molecular cell organization
  2. Introduction to the study of biological molecules
  3. Amino acids and Proteins
  4. Enzyme kinetics
  5. Carbohydrates
  6. Lipids
  7. Metabolisms
  8. Plasma membrane
  9. Cell-cell and cell-matrix adhesion
  10. Transmembrane transport
  11. Cytoskeleton
  12. Cell cycle. Chromatin and chromosomes
  13. Basic genetic mechanisms
  14. Mutagenesis, mutations and genetic variation
  15. Inheritance and chromosomal bases of genetic diseases
Suggested Bibliography:
  • Lodish H, Berk A, Kaiser CA, Krieger M, Bretscher A, Ploegh H, Amon A, Scott MP (2016). Molecular Cell Biology, 8th ed., W. H. Freeman and Company, New York.
  • Azevedo C, Sunkel CE (2012). Biologia Celular e Molecular. 5th ed. Lidel, edições técnicas, Lisboa.
  • Griffiths AJF et al. (2015). An Introduction to Genetic Analysis. 11th ed., W. H. Freeman.
  • Quintas A, Ponces A, Halpern MJ (2008) Bioquímica: Organização Molecular da vida, Lidel, Lisboa, Portugal.
  • Nelson DL, Cox MM (2004) Lehninger Principles of Biochemistry. 4th ed., Worth Publishers Inc., New York, EUA.
  • Devlin TM (2001) Text Book of Biochemistry with Clinical Correlations, 5th ed., Wiley-Liss, New York, EUA.