Toxicology
Toxicologia
Course code:9494443
Maria Deolinda Ferreira dos Santos Auxtero
Learning outcomes of the curricular unit:
Toxicology is the study about the harmful effects of chemical substances (also of physical or biological nature) in living beings. It is a multidisciplinary matter including pharmacology, biochemistry, chemistry, physiology and others. The raising interest and scope of Toxicology is explained by its major importance for the well-being of man and other living beings. The steady growth in the number of new chemicals, pharmaceuticals, pesticides, pollutants, drugs of abuse, food additives, etc., associated with their potential toxicity, constitutes the support and justification for the commitment that must be given to the study of this discipline. The pharmacist, for its multi-disciplinary training and opportunities for any intervention in his professional life, occupies a place of honor to fit in this scientific area and receive proper formation.
In the laboratory classes the objective is to provide practical knowledge in relation to analytical toxicology and the interpretation of results.
Syllabus:
- Introduction to Toxicology
- Classification of toxic/harmful effects of chemical agents
- Dose-response relationship
- Toxicokinetics and Biotransformation
- Cellular Bases of Toxic Injury
- Mechanisms of toxicity
- Chronic toxicity
- Acute toxicity
- Neurotoxicology
- Behavioral Toxicology
- Drugs of abuse and Addiction
- Clinical Toxicology
- Ecotoxicology
- Occupational Toxicology
- Food Toxicology
- Experimental Toxicology
- Nanotoxicology
Suggested Bibliography:
- Klaassen CD (2013) Casarett and Doull’s Toxicology - The Basic Science of Poisons, 8th ed., McGraw-Hill. New York. ISBN 978-0-07-176923-5
- Reichl F, Ritter L (2011) Illustrated Handbook of Toxicology, Ed. Thieme New York, ISBN 978-3-13-126921-8
- Repetto M (2009) Toxicologia Fundamental, 4th ed., Diaz de Santos, Madrid. ISBN 978-84-7978-898-8
- Hodgson E (2004) A Textbook of Modern Toxicology. Appleton & Lange, Stamford. ISBN 978-0-47-126508-5
- Flanagan RJ et al. (2007) Fundamentals of analytical toxicology. John Wiley & Sons. ISBN 978-0-470-31934-5