Curse code:C9494326

Maria Deolinda Ferreira dos Santos Auxtero

Learning outcomes of the curricular unit:

This subject covers the basic methodologies of pharmacokinetic analysis in a biopharmaceutical and clinical setting. It includes the qualitative and quantitative description of the factors that influence drug availability and disposition. It also aims to demonstrate the applicability of theoretical concepts, and clinical applications of pharmacokinetics.

In summary, upon completion of the course, students should be able to:

  • Identify pharmacokinetic models using drug plasma and urinary data.
  • Determine pharmacokinetic parameters such as Vd, Cl, Ke, half-life, AUC, amongst other.
  • Analyze drug plasma concentration-time profiles and to make therapeutic adjustments.
  • Define posologic regimens and adjust them if necessary.
  • Elaborate a TDM (therapeutic drug monitoring) plan.
  • Identify the pharmacokinetic and biopharmaceutical implications of the several routes of drug administration and drug design forms.
  • Adjust drug administration regimens in patients with renal injuries.
  1. Biopharmacy: concept and applications.
  2. Concept of model.
  3. Administration by intravenous bolus.
  4. Multiple doses.
  5. Intravenous infusion.
  6. Distribution.
  7. Elimination.
  8. Bi-exponential model.
  9. Oral administration.
  10. Urinary data.
  11. Metabolism.
  12. Therapeutic Drug Monitoring and dosage adjustments.
  13. Non-linear kinetics.
  14. Mean time parameter in pharmacokinetics.
Suggested Bibliography:
  • Spruill JW, Wade EW, DiPiro JT, Blouin RA, Pruemer JM (2014) Concepts in Clinical Pharmacokinetics. 6th ed., American Society of Health-System Pharmacists. ISBN: 978-1-58528-3873.
  • Tozer TN & Malcolm R (2006) Introduction to pharmacokinetics and pharmacodynamics: the quantitative basis of drug therapy. Philadelphia: Lippincott Williams & Wilkins. ISBN: 0-7817-5149-7.
  • Hedaya MA (2012) Basic pharmacokinetics. 2nd ed., New York: CRC Press + 1 CD-Rom. (CRC Press pharmacy education series). ISBN: 1-4398-5073-9.
  • Curry SH & Whelpton R (2017) Introduction to Drug Disposition and Pharmacokinetics. 1st ed., John Wiley and Sons Ltd. ISBN: 1-11926-104-X.
  • Ritschel WA & Kearns GL (2009) Handbook of basic pharmacokinetics: including clinical applications. 7th ed., Washington: American Pharmacists Association. ISBN: 1-58212-126-5.


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