Pharmacy

1Organic Chemistry I

Quimica Orgânica I

Course code:9494115

Luísa Maria Lima Gonçalves

Learning outcomes of the curricular unit:

This unit contribute to the topics A, C, J, K, L of the Pharmaceutical Act, described in DL 288/2001. Its aim is to provide students with general knowledge of organic compounds.

After having completed this course, the student should be able to:
  • Represent mono- and polyfunctional organic compounds using IUPAC name or structure.
  • Characterize molecules according to the polarity. Compare organic molecules for physical constants such as melting and boiling points and solubility in water.
  • Represent acyclic and cyclic organic molecules in stereochemistry projections. Interpret the potential energy / stability of the various conformations. Distinguish stereoisomers.
  • Compare the strength of Lewis acids and bases.
  • Characterize the main mechanisms of radical and ionic reaction.
  • Recognize reactions of nucleophilic substitution and distinguish SN1 and SN2 reactions.
Syllabus:
  1. Introduction to Organic Chemistry
  2. Nomenclature in Organic Chemistry
  3. Isomerism and stereoisomerism
  4. Electronic Effects: Inductive and mésoméric effects
  5. Organic acids and bases
  6. Reaction mechanisms
  7. Nucleophilic reactions: Nucleophilic substituition
Suggested Bibliography:
  • Dewick PM (2006) Essentials of Organic Chemistry: For Students of Pharmacy, Medicinal Chemistry and Biological Chemistry. Wiley. ISBN: 978-0-470-01666-4.
  • Timberlake KC (2014) An Introduction to General, Organic, and Biological Chemistry. 12th ed., , Prentice Hall ed. ISBN-13: 978-0321908445.
  • Campos LS & Mourato M (2002) Nomenclatura dos Compostos Orgânicos. Escolar Editora, Lisboa. ISBN: 972-592-107-0.
  • Solomons GT & Freyhle CB (2012) Química Orgânica. 9th ed., Ed. LTC. ISBN: 9788521620334.
  • Morais ZB & Silva PC (2004) Exercícios de Estereoquímica em Química Orgânica. Ed. Sílabo, Lisboa. ISBN 972-618-335-9.