Drug Design
Design de fármacos
Course code:9494328
Carla Susana Silva Dias Reis Ascenso
Learning outcomes of the curricular unit:
The current course is focused on the study of the basic principles of drug design and development, in a perspective that aims to develop knowledge and understanding of the relations between the chemical structure of a particular drug/lead and the resulting activity. The approach is centered on the identification of the chemical groups in the developing molecule that should be added/replaced in order to improve the pharmacokinetics and pharmacodynamics of a drug candidate. Drug activity is predicted by means of specific algorithms, both avoiding the expensive and time consuming process of chemical synthesis and simultaneously considering as much group candidates as possible.
Syllabus:
- Principles of Rational Drug Design and Development
- Optimizing target interactions
- Optimizing access to the target
- Lead Compound Discovery Strategies
- Introduction to Quantitative Approaches of Structure-Activity Relationships
Suggested Bibliography:
- Patrick GL (2009) An introduction to medicinal chemistry, 4th ed. Oxford University Press. ISBN 0199234477
- Wermuth CG (2008) The practice of medicinal chemistry, 3rd ed., Elsevier Ltd. ISBN 9780123741943
- Nogrady T (2005) Medicinal chemistry – A molecular and biochemical approach, 3rd Ed., Oxford University Press. ISBN 0195104560
- Satyanarayanajois SD (2011) Drug design and discovery - Methods and protocols. Humana Press, Springer. ISBN 10643745