Pharmaceutical Technology II

Tecnologia Farmacêutica II

Curse code:9494331

Ana Isabel Henriques Dias Fernandes Pinto

Learning outcomes of the curricular unit:

Provide students with the theoretical and practical knowledge adequate to the design, formulation, production and quality control of solutions, emulsions and suspensions, topical semi-solids, vaginal and rectal dosage forms, and the sterile products for parenteral and ocular use.

It is intended that students learn how to produce and control the quality of the dosage forms under study, and to promote:

• the acquisition and development of research attitudes and reflection,
• group work and, simultaneously, develop individual leadership and communication skills, as well as critical thinking.

At the end of this course students should be able to recognize the advantages and limitations of the use of the therapeutic dosage forms under study and apply the most recent scientific and technological knowledge in the maximization of their effectiveness.

Syllabus:

1. SOLUTIONS
   Oral solutions (syrups), nasal, auricular, rectal, vaginal, antiseptic, disinfectant
   Raw materials, manufacturing technology, packaging and quality control
2. EMULSIONS
   Emulsification and emulsion instability
   Raw materials, manufacturing technology, packaging and quality control
3. SUSPENSIONS
   Flotation and sedimentation of particles; crystal growth ; redispersibility
   Raw materials, manufacturing technology, packaging and quality control
4. TOPICAL SEMISOLIDS
   Ointments, pastes, gels, creams, poultices, plasters and foams
   Raw materials, manufacturing technology, packaging and quality control
5. SUPPOSITORIES AND PESSARIES
   Raw materials, manufacturing technology, packaging and quality control
6. STERILE DOSAGE FORMS (PARENTERAL AND OPHTHALMIC)
   Raw materials, manufacturing technology, packaging and quality control
   Isotonization
   Sterilization

Suggested Bibliography:

• Lachman L, Lieberman HA, Kanig JL (eds) (2010) Teoria e Prática na Indústria Farmacêutica, 2ª ed., Fundação Calouste Gulbenkian, Lisboa. ISBN: 9789723109085.
• Aulton ME (ed.) (2013) Aulton's Pharmaceutics: the Design and Manufacture of Medicines, 4th ed., Churchill Livingstone, Edinburgh. ISBN: 9780702042904.
• Florence AT, Siepmann J (2009) Modern Pharmaceutics, 5th ed., Informa Healthcare, New York. ISBN: 9781420065701.
• Lieberman HA, Rieger MM, Banker GS (eds) (1996) Pharmaceutical Dosage Forms: Disperse Systems Vol. I, II e III, 2nd ed., Marcel Dekker, Inc., New York. ISBN: 0824793870, 0824797132, 0824798422.
• Avis KE, Lieberman HA, Lachman L (eds) (2010) Pharmaceutical Dosage Forms: Parenteral Medications Vol. I, II e III, 3rd ed., Marcel Dekker, Inc., New York. ISBN: 9781420086539