Pharmaceutical Biotechnology
Biotecnologia Farmacêutica
Curse code:9494441
Perpétua da Conceição Rodrigues Gomes Cavaco Silva
Learning outcomes of the curricular unit:
Lectures
Main objective is to form the new pharmacists in an extremely important and actual area: the biotechnological production of pharmaceutical products thought the use of recombinant DNA technology, manipulation of microorganisms and/or plants, animals or human. The most recent biotechnological methods for obtaining several compounds as well as processes for the regulation of these techniques are presented. It is promoted a detailed and informed debate on the pharmaceutical perspective.
Lab practice classes
Enabling the learning of methodologies in the area of Industrial Pharmaceutical Biotechnology and promote the development of scientific and technological capabilities. The student should be capable of organizing and planning, have the capacity to manage information (search, selection and interpretation), ability to work and learn in teamwork, have critical capacity, ethical and social responsibilities recognizing.
Syllabus:
- Fundamentals of Biotechnology
- Techniques used in biotechnology
- Production of compounds in biotechnology - biologics
- Microbial synthesis of commercial products
- Monoclonal Antibodies in Pharmaceutical Sciences
- Vaccines and therapeutic agents
- Biosimilars. Management of Biological Products
- Plant Biotechnology. Fundamentals of plant biotechnology. Plant transformation. In vitro and in vivo production of phytochemicals
- Production of proteins and animals antibodies by transgenic plants
- Animal Biotechnology. Methods of obtaining transgenic animals and reproductive cloning. Production of therapeutic proteins
- Human Biotechnology. Human gene therapy. Stem cells. Therapeutic cloning
- Nanotechnology. Regulatory and Patents. Ethical issues. Debate.
Suggested Bibliography:
- Gary Walsh. (2003) “Biopharmaceuticals: Biochemistry and Biotechnology”, 2nd ed., Wiley-Blackwell. ISBN-13: 978-0470843277
- Crommelin, D.J.A., Sindelar, R.D. and Meibohm, B. (2007) “Pharmaceutical Biotechnology: Fundamentals and Applications” 3rd ed., Informa Healthcare. ISBN-13: 978-1420044379
- Gad, S.C. (2007) “Handbook of Pharmaceutical Biotechnology”, Wiley-Blackwell. ISBN-13: 978-0471213864
- Lima, N.; Mota, M. (2003) “Biotecnologia. Fundamentos e Aplicações”, Ed: Lidel, Lisboa, Portugal