Cell and Molecular Biology II
Biologia Celular e Molecular II
Curse code:9548113
Isabel Maria Correa Calvente de Barahona
Learning outcomes of the curricular unit:
The aim of this curricular unit is the acquisition of fundamental concepts regarding the functioning of living systems, studying in detail the simplest living system, the cell and their interactions with the environment.
Students knowledge acquired previously will be developed, i.e. students should be able to explain at the molecular level the functioning of the cell and to understand different regulatory mechanisms which are indispensable for the proper functioning of living beings.
The knowledge gained in molecular biology has implications in medical practice, in particular in understanding different diseases that will be discussed and analysed.
Syllabus:
- CELLULAR SIGNALING
Different signalling pathways that control the activity of genes associated with different receptors. - CELL CYCLE CONTROL AND CELL GROWTH
Regulation mechanisms of the cell cycle. - CELL LINEAGES, BIRTH AND CELL DEATH
Stem cell and cellular lineage.
Differentiation.
Cell death and its regulation. - MECHANISMS OF TRANSPORT OF MOLECULES
Transport of small and large molecules through membranes. - INTRACELLULAR PROTEIN TRAFFIC
Signalization and forwarding of proteins to different organelles.
Molecular mechanisms of protein transport through the membranes.
Secretion pathway.
Vesicles. - GENERAL AND SPECIFIC CELL MOVEMENT OF MUSCLE AND NERVE CELLS CYTOSKELETON
Microfilaments.
Mechanisms of muscle contraction.
Microtubules: structure and diversity of microtubules. Kinetic and structural polarity of microtubules. Intracellular transport through microtubules.
Cilia and flagella intermediate filaments.
Suggested Bibliography:
- Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Amon and Scott (2013) Molecular Cell Biology. 7th ed, W.H. Freeman and Company, New York. ISBN-13 978-1-4641-0981-2.
- Cooper, G.M. and Hausman, R.E. (2013) The Cell, a Molecular Approach. 6th ed, Sinauer Associates, Inc., USA. ISBN: 978-1-60535-155-1.
- Alberts B, Johnson A, Lewis J, Raff M (2007) Molecular Biology of the Cell. 5th ed., Garland Publishing, Inc., London. ISBN 978-0-8153-4105-5.
- Alberts K, Roberts K, Lewis J, Hopkin K, Johnson A, Walter P, Raff M, Bray D (2003) Essential cell biology: an introduction to the molecular biology of the cell. 2nd ed., Garland Publishing, Inc., New York & London. ISBN-13: 9780815334804.
- Azevedo C, Sunkel CE (2012) Biologia Celular e Molecular, 5ª ed., Lidel, edições técnicas, Lisboa. ISBN 978-972-757-692-0.