Health Sci.



Curse code:9822304

Luísa Maria Lima Gonçalves

Learning outcomes of the curricular unit:

It is intended that the student apprehends the general principles of human toxicology, in areas such as food, forensics, occupational and clinical toxicology. To develop the ability to identify, classify and evaluate the potential hazards associated with different classes of xenobiotics, and their impact on human health. Also aims at the student to perceive the general concepts about Risk Assessment and Biomarkers, acquire generic knowledge of the techniques/ analytical methods used in quantitative and qualitative analysis of toxic compounds in biological fluids, food and environmental samples (soil and water).

  • Identify and describe the major classes of toxic agents in the context of food, forensic, occupational and clinical toxicology.
  • Describe the mechanisms of toxicity induced by xenobiotics.
  • Recognize the importance of individual inter-variability in response to chemical and biological agents and their relationship with the risk of developing various diseases.
  1. General Principles of Toxicology.
  2. Pharmacokinetics of Xenobiotics.
  3. Concepts of Pharmacodymamics.
  4. Applied Toxicology - Food Toxicology, Occupational Toxcicology, Clinical Toxicology and Forensic Toxicology.
Suggested Bibliography:
  • Klassen CD, Eaton DL (1996) Casarett & Doull’s Toxicology – The Basic Science of Poisons, 5th ed., Ed. McGraw-Hill Ed., New York. ISBN: 0-07-105476-6.
  • Flanagan RJ, Taylor AA, Watson ID, Whelpton R (2007) Fundamentals of analytical toxicology, John Wiley & Sons. ISBN: 978-0-470-31934-5.
  • Desphande SS (2002) Handbook of Food Toxicology. Ed. Marcel Dekker Inc, Nova York. ISBN: 0-8247-0760-5.
  • Karch BS (Ed.) (2008) Pharmacokinetics and pharmacodynamics of abused drugs, New York: Taylor & Francis Group, CRC Press. ISBN: 1-4200-5458-9.
  • Karch SB (2007) Drug abuse handbook, Taylor & Francis Group (Ed.), CRC Press. ISBN: 0-8493-1690-1.


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