Dental Prosthesis

Oral Biochemistry2

Bioquímica Oral

Course code:9791126

Carlos Manuel Lopes Monteiro

Learning outcomes of the curricular unit:

Biochemistry's goal is the complete understanding, at the molecular level, of all of the chemical processes associated with living cells. Therefore, the main purpose of this curricular unit is to integrate the knowledge of general biochemistry into topics that specifically pertain to dental health and disease.
Thus, in the end of the curricular unit, the Dental Prosthesis students should be able to know the chemical, metabolic and nutritional aspects of the stomatognathic system in order to understand the fundamental principles of the biochemical processes of the human’s tissues, including the mineralization of tooth. They also need to take into account the biochemical aspects applied to Dentistry.

Syllabus:
  1. BASIC CONCEPTS IN BIOCHEMISTRY
    Biological polymers: Amino acids, peptides and proteins. Carbohydrates and lipids.
    Mechanisms of energy production: Respiration and fermentation.
  2. EXTRACELLULAR MATRIX OF CONNECTIVE TISSUE AND ITS MAJOR COMPONENTS
    Collagen. Elastic fiber system. Glycosaminoglycans.
    Teeth, alveolar bone and periodontium.
  3. FIBRILLLAR AND NON-FIBRILLAR COLLAGENS AND INTEGRINS
  4. BASAL LAMINAS AND EPITHELIA
  5. ELASTIC FIBERS AND PROTEOGLYCANS
  6. COLLAGEN SYNTHESIS, GENETIC DISEASES AND SCURVY
  7. PROCESSING AND DEGRADATION OF THE COLLAGEN FIBERS
  8. BIOLOGICAL MINERALIZATION
    Nature of the apatite precipitate.
    The structures of bone, dentin and cementum. Mechanisms of mineralization.
    Proposed mechanism of enamel synthesis.
  9. BONE REMODELING AND CALCIUM METABOLISM
    Bone turnover. Demineralization and remineralization.
    Calcium metabolism, parathyroid hormone and calcitriol. Vitamin D.
    Actions of calcitonin.
  10. SALIVA
  11. BIOCHEMISTRY OF DENTAL CARIES AND PERIODONTAL DISEASE
  12. MECHANISMS OF PROTECTION OF DENTAL CARIES BY FLUORIDE
    Systemic effects of fluoride. Fluoride toxicity.
 
Suggested Bibliography:
  • Levin M (2011) Topics in Dental Biochemistry, Ed. Springer-Verlag, Berlin Heidelberg. ISBN: 978-3-540-881155.
  • Vasudevan D, Sreekumari S, Vaidyanathan K (2011) Textbook of Biochemistry for dental Students, 2nd ed., Ed. Jaypee Brothers Medical Publishers. ISBN: 978-93-5025-488-2.
  • Lehninger (2008) Principles of Biochemistry, D.L. Nelson and M.M. Cox, 5th ed., Worth Publishers.
  • Stryer L (1999) Biochemistry, 3rd ed., W. H. Freeman and Company, NY.
  • Voet D, Voet J, Pratt C (1999) Fundamentals of Biochemistry, Jonh Wiley & Sons – NY.