Biomedical Lab Sci

Clinical Pathology I2

Patologia Clinica I

Course code:68204

Sérgio Valério

Learning outcomes of the curricular unit:

The CU of Clinical Pathology I aims to introduce, guide and explain the use of Clinical Laboratory through the explanation of the various phases and components of the analytic process; the type of biological samples and collection guidelines, transport storage and handling; the principles and proper use of general analytical methods, laboratory equipment as well as more specific instrumental methods, the aspect of automation and its methodologies.
Students will learn the types and importance of the support of information technology to global analytic process; It will also be addressed the type and the emission of results, the process of validating results and the reference values, underpinned by a statistical process of obtain and control the values. The bases and methods of procedure of Quality Control to support integration of analytic process are addressed.

  1. Introduction to Clinical Pathology.
  2. Clinical Pathology Laboratory.
  3. Types of organic products, harvests, transport, preparation and preservation of organic products.
  4. The analytical process: Phases and analytical flow.
  5. General analytical methodologies.
  6. Laboratory results: typology, emission and interpretation.
  7. Supra renal, its pathology (pheochromocytoma), clinical manifestations.
  8. Cushing's syndrome, its pathology and clinical manifestations.
  9. Injury and cellular adaptation: causes types and principles. Morphology of damaged cells. Changes.
  10. Inflammation and repair: Acute and chronic inflammation, morphological patterns, systemic effects, healing and repair.
  11. Water and hemodynamic disorders: edema, hyperemia and congestion, thrombosis, normal hemostasis, embolism, infarction, shock.
  12. Blood vessels: pathological changes.
  13. Immunity: injury mechanisms mediated by immune processes (hypersensitivity reactions), tissue transplantation.
  14. Erythrocytes and hemostasis - pathologies and clinical characteristics. Anemia, polycythemia, hemorrhagic disorders.
  15. Leukocytes, lymph nodes and spleen: leukopenia, reactive leukocyte and lymph node proliferations; Neoplastic leukocyte proliferations; Malignant lymphomas; Leukemias and myeloproliferative diseases; Plasmacyte dyscrasias and correlated disorders; Langerhans cell histiocytosis; Splenomegaly, reactive hyperplasia of the spleen; Congestive splenomegaly.
Suggested Bibliography:
  • Mitchell R, Aster J, Kumar V & Abbas AK (2017) Robbins & Cotran Fundamentos de Patologia. 9th ed. Elsevier.
  • Burtis C & Bruns D (2007) Tietz Fundamentals of Clinical Chemistry, 6th ed. Saunders