Pharmacokinetics
Farmacocinética
Curse code:C9494326
Maria Deolinda Ferreira dos Santos Auxtero
Learning outcomes of the curricular unit:
This subject covers the basic methodologies of pharmacokinetic analysis in a biopharmaceutical and clinical setting. It includes the qualitative and quantitative description of the factors that influence drug availability and disposition. It also aims to demonstrate the applicability of theoretical concepts, and clinical applications of pharmacokinetics.
In summary, upon completion of the course, students should be able to:
- Identify pharmacokinetic models using drug plasma and urinary data
- Determine pharmacokinetic parameters such as Vd, Cl, Ke, half-life, AUC, amongst other
- Analyze drug plasma concentration-time profiles and to make therapeutic adjustments
- Define posologic regimens and adjust them if necessary
- Elaborate a TDM (therapeutic drug monitoring) plan
- Identify the pharmacokinetic and biopharmaceutical implications of the several routes of drug administration and drug design forms
- Adjust drug administration regimens in patients with renal injuries
Syllabus:
- Biopharmacy: concept and applications
- Concept of model
- Administration by intravenous bolus
- Multiple doses
- Intravenous infusion
- Distribution
- Elimination
- Bi-exponential model
- Oral administration
- Urinary data
- Metabolism
- Therapeutic Drug Monitoring and dosage adjustments
- Non-linear kinetics
- Mean time parameter in pharmacokinetics
Suggested Bibliography:
- DiPiro JT, et al. (2010) ”Concepts in Clinical Pharmacokinetics” 5th ed., Bethesda : American Society of Health-System Pharmacists. ISBN 1-58528-051-8
- Tozer TN (2007) “Introduction to pharmacokinetics and pharmacodynamics: the qualitative basic of drug therapy” Philadelphia: Lippincott Williams & Wilkins. ISBN 0-7817-5149-7
- Hedaya MA (2007) “Basic pharmacokinetics” New York: CRC Press, + 1 CD-Rom. (CRC Press pharmacy education series). ISBN 1-4200-4671-3
- Curry SH(1987) “Clinical pharmacokinetics : the MCQ approach” New Jersey : The Telford Press. ISBN 0-936923-02-4
- Ritschel WA, Kearns GL (2004) “Handbook of basic pharmacokinetics: including clinical applications” 6th ed., Washington: American Pharmaceutical Association, cop. ISBN 1-58212-054-4