Pharmaceutical Technology I

Tecnologia Farmacêutica I

Curse code:9494325

Miguel Ângelo da Costa Garcia

Learning outcomes of the curricular unit:

• Acquisition of theoretical and practical knowledge about the current state of Pharmaceutical Technology regarding the development, preparation, quality control and packaging of solid dosage forms.

Syllabus:

1. Pre-Formulation.
   Introduction
   Organoleptic Properties
   Purity
   Particle size, shape and surface area
   Solubility
   Dissolution
   Parameters that affect absorption
   Crystal Properties and polymorphism
   Stability
   Other properties
   Applied studies
2. Powders.
   Introduction
   Granulometric analysis
   Reduction of Dimensions
   Blending
   Rheology
3. Dosage forms derived from powders.
   Powders
   Granulates / Granules
   Capsules
   Tablets
   Coated Tablets

Suggested Bibliography:

• Farmacopeia Portuguesa (2008) IX Edição, Infarmed. CDD: r615.11 F247
• Aulton ME (2007) Aulton’s Pharmaceutics: The design and manufacture of medicines. 3rd ed., Churchill Livingstone, Edinburgh. ISBN 978-443-10108-3
• Aulton ME (ed.). (1994) Pharmaceutics: The Science of Dosage Forms Design, Churchill Livingstone, Edinburgh. ISBN 0-443-03643-8
• Prista LN, Correia AA, Morgado RMR (1992) Técnica Farmacêutica e Farmácia Galénica. 4th ed., Fundação Calouste Gulbenkian, Lisboa, Vol I, II e III. CDD:615.19 P955T
• Lachman L, Lieberman HA, Kanig JL (2010) Teoria e Prática na Indústria Farmacêutica. Ed. Fundação Calouste Gulbenkian. Trad. of "The Theory and practice of industrial pharmacy" by Pinto J and Fernandes JP. ISBN 978-972-31-0908-5