General and Analytical Chemistry
Química Geral e Analítica
Curse code:9494118
Maria Alexandra Sardinha Bernardo
Learning outcomes of the curricular unit:
Through this course students must acquire the basic knowledge in molecular behavior needed to improve their comprehension on the chemical and physical events. This course is design to include laboratory lessons were students should experience and understand the most common techniques used in the modern chemistry laboratory.
Students must also become familiar with quantitative analytical chemistry calculations and appropriate selection along with the execution of available laboratory procedures.
The knowledge, theoretical and practical, acquired in this unit of study will be the basis in areas of knowledge of pharmaceuticals (eg. organic chemistry, pharmaceutical chemistry, pharmaceutical technology, galenic pharmacy, pharmacognosy and toxicology).
Syllabus:
- CHEMICAL LABORATORY:
General Methodology / Methods of Measurement and Separation
Solutions: Concentrations, dilutions and units. Physical properties of solutions and prediction of solubility
Heating and Cooling. Reduced pressure. Drying (conduction, convection and IV)
Filtration (Darcy's law). Measuring volumes of liquids and transfer
Boiling point. Melting / freezing. Densities
Absorption of Light and Beer-Lambert Law
Unit Operations of Separation
Purification solid and liquids - CHEMICAL EQUILIBRIA AND ANALYTICAL TECHNIQUES
Acid-Base Equlibria
Exact and approximate methods for determining the pH of aqueous solutions
Acid-base indicators
Solubility Equlibria
Redox Equlibria
Oxidation-reduction and balance sheets
Standard electrode potential: potential for reduction and oxidation. Nernst equation
Calculation of potential solution along titration curves
Redox indicators
Suggested Bibliography:
- Arthur Israel Vogel (1994) Vogel's textbook of practical organic chemistry; 5th ed., rev. Brian Stanley Furniss et al., Essex : Longman Scientific and Technical. ISBN 0-582-46236-3.
- Chang R (1991) Chemistry: international edition, 4th ed., New York:Lisboa, McGraw-Hill. ISBN 0-07-010518-9
- Reger D (1997) Química: princípios e aplicações. Lisboa: Fundação Calouste Gulbenkian. ISBN 972-31-0773-2
- Skoog DA (2004) Fundamentals of analytical chemistry, 8ªed., Belmont, CA : Thomson-Brooks/Cole. ISBN 13: 978-0-534-41797-0
- Simões JAM et al. (2000) Guia do laboratório de química e bioquímica. Lisboa : Lidel. ISBN 972-757-146-8
- Brown TL et al. (2009) Chemistry: the central science, 11th ed., New Jersey : Pearson Prentice Hall. ISBN 0-13-235848-4
- Atkins P(2006) Physical chemistry for the life sciences. Oxford : Oxford University Press. ISBN 978-0199-28095-7